Atypical disseminated intravascular coagulopathy during bubonic plague

Powerful pathogens such as Bacillus anthracis and Yersinia pestis cause severe hemorrhagic syndromes that have previously been attributed to a Disseminated Intravascular Coagulopathy (DIC). However, the data attesting this statement are missing or contradictory. This study aimed at determining whether DIC do occur late stages of plague anthrax. Using mouse models cutaneous anthrax bubonic plague, we observed most B. anthracis-infected animals exhibited increased partial thromboplastin time (aPTT) prothrombin (PT), along with dynamic consumption fibrinogen, matching characteristics an overt DIC. In contrast, only heavily Y. pestis-infected mice displayed aPTT, but little fibrinogen no increase PT were in infected animals, even infection. Therefore, coagulopathy develops during is compatible classical DIC, while not present typical parameters. suggests mechanism involved hemorrhages exhibits specific, atypical pattern. It then important understand how these triggered.